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Synthetische Biologie

A Chimeric Siderophore Halts Swarming Vibrio

T. Böttcher, J. Clardy (2014). Angewandte Chemie Int. Ed. 53(13): 3510-3513

Synthesis and activity of biomimetic biofilm disruptors

T. Böttcher, I. Kolodkin-Gal, R. Kolter, R. Losick, J. Clardy (2013). J. Am. Chem. Soc. 135(8): 2927-30

ß-Lactams and ß-lactones as activity-based probes in chemical biology

T. Böttcher, S. A. Sieber (2012). Med. Chem. Comm. 3: 408-417

A conformational switch underlies ClpP protease function

S. Geiger*, T. Böttcher*, S. A. Sieber, P. Cramer (2011). Angewandte Chemie Int. Ed. 50(25): 5749-5752

Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria

T. Böttcher, S. A. Sieber (2010). J. Am. Chem. Soc. 132(20): 6964-72

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

T. Böttcher, S. A. Sieber (2008). J. Am. Chem. Soc. 130(44):14400-14401

Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes

T. Böttcher, S. A. Sieber (2008). Angewandte Chemie Int. Ed. 47(24): 4600-4603