Thomas Böttcher

Thomas Böttcher

Member since 2015
born 1982
subject: Chemistry/biological Chemistry

Universität Konstanz
Fachbereich Chemie
Universitätsstraße 10
78457 Konstanz

Tel.: (07531) 88 57 66

Personal web page

Research Areas

  • natural product isolation and structure elucidation

  • microbial metabolites

  • bacterial population behaviour

  • organic synthesis

  • chemical probes

  • antibiotics


Curriculum Vitae

  • since 2014

    Emmy-Noether group leader, University of Konstanz

  • 2014

    ZIF Marie Curie Research Fellowship

  • 2011-2014

    Postdoc, Harvard Medical School with a Leopoldina-Postdoc-Fellowship

  • 2010-2014

    Science manager and associate of AVIRU GmbH

  • 2010-2011

    Cofounder and project leader of the EXIST transfer of research project AVIRU

  • 2010

    Klaus Tschira award for achievements in public understanding of science

  • 2010

    Postdoc, Technical University of Munich

  • 2009

    Römer-Award of the Departments Chemistry and Biochemistry, LMU

  • 2006-2009

    PhD studies in Organic Chemistry at the Ludwig-Maximilians-University Munich with a Doctoral fellowship of the German National Academic Foundation

  • 2003-2006

    Studies of Chemistry and Biochemistry Ludwig-Maximilians-University Munich


  • A Chimeric Siderophore Halts Swarming Vibrio

    T. Böttcher, J. Clardy (2014). Angewandte Chemie Int. Ed. 53(13): 3510-3513

  • Synthesis and activity of biomimetic biofilm disruptors

    T. Böttcher, I. Kolodkin-Gal, R. Kolter, R. Losick, J. Clardy (2013). J. Am. Chem. Soc. 135(8): 2927-30

  • ß-Lactams and ß-lactones as activity-based probes in chemical biology

    T. Böttcher, S. A. Sieber (2012). Med. Chem. Comm. 3: 408-417

  • A conformational switch underlies ClpP protease function

    S. Geiger*, T. Böttcher*, S. A. Sieber, P. Cramer (2011). Angewandte Chemie Int. Ed. 50(25): 5749-5752

  • Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria

    T. Böttcher, S. A. Sieber (2010). J. Am. Chem. Soc. 132(20): 6964-72

  • Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

    T. Böttcher, S. A. Sieber (2008). J. Am. Chem. Soc. 130(44):14400-14401

  • Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes

    T. Böttcher, S. A. Sieber (2008). Angewandte Chemie Int. Ed. 47(24): 4600-4603

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