Thomas Böttcher
Member since 2015
born 1982
subject: Chemistry/biological Chemistry
Contact
Universität Konstanz
Fachbereich Chemie
Universitätsstraße 10
78457 Konstanz
Tel.: (07531) 88 57 66
thomas.boettcher@uni-konstanz.de
Research Areas
natural product isolation and structure elucidation
microbial metabolites
bacterial population behaviour
organic synthesis
chemical probes
antibiotics
Curriculum Vitae
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since 2014
Emmy-Noether group leader, University of Konstanz
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2014
ZIF Marie Curie Research Fellowship
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2011-2014
Postdoc, Harvard Medical School with a Leopoldina-Postdoc-Fellowship
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2010-2014
Science manager and associate of AVIRU GmbH
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2010-2011
Cofounder and project leader of the EXIST transfer of research project AVIRU
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2010
Klaus Tschira award for achievements in public understanding of science
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2010
Postdoc, Technical University of Munich
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2009
Römer-Award of the Departments Chemistry and Biochemistry, LMU
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2006-2009
PhD studies in Organic Chemistry at the Ludwig-Maximilians-University Munich with a Doctoral fellowship of the German National Academic Foundation
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2003-2006
Studies of Chemistry and Biochemistry Ludwig-Maximilians-University Munich
Activities
Publications
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A Chimeric Siderophore Halts Swarming Vibrio
T. Böttcher, J. Clardy (2014). Angewandte Chemie Int. Ed. 53(13): 3510-3513
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Synthesis and activity of biomimetic biofilm disruptors
T. Böttcher, I. Kolodkin-Gal, R. Kolter, R. Losick, J. Clardy (2013). J. Am. Chem. Soc. 135(8): 2927-30
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ß-Lactams and ß-lactones as activity-based probes in chemical biology
T. Böttcher, S. A. Sieber (2012). Med. Chem. Comm. 3: 408-417
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A conformational switch underlies ClpP protease function
S. Geiger*, T. Böttcher*, S. A. Sieber, P. Cramer (2011). Angewandte Chemie Int. Ed. 50(25): 5749-5752
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Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria
T. Böttcher, S. A. Sieber (2010). J. Am. Chem. Soc. 132(20): 6964-72
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Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus
T. Böttcher, S. A. Sieber (2008). J. Am. Chem. Soc. 130(44):14400-14401
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Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes
T. Böttcher, S. A. Sieber (2008). Angewandte Chemie Int. Ed. 47(24): 4600-4603
