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Sven Diederichs

Sven Diederichs

Member from 2010 to 2015
subject: Biochemistry

Contact
Deutsches Krebsforschungszentrum Heidelberg
Molekulare RNA Biologie & Krebs (B150)
Im Neuenheimer Feld 280
69120 Heidelberg

Tel.: (06221) 42 43 83
s.diederichs@dkfz.de

Personal web page

Research Areas

  • Molecular biology

  • Cell biology

  • Tumor biology

  • RNA biology: function, regulation and biogenesis of microRNAs and long, non-coding RNAs in cancer cells

 

Curriculum Vitae

  • since 2015

    Head of the "RNA Biology and Cancer" department at German Centre for Cancer Research and the Pathological Institute, Heidelberg University

  • 2013

    Dr. Hella Bühler-Prize for Cancer Research

  • 2012

    Binder Innovation Prize of the German Society for Cell Biology (DGZ)

  • 2010

    Karl Freudenberg Prize from the Heidelberg Academy of Sciences

  • since 2008

    Head of the Independent Helmholtz University Junior Research Group 'Molecular RNA Biology & Cancer' at the German Cancer Research Centre and the Pathological Institute of the University of Heidelberg

  • 2005-2008

    Postdoctoral Fellow at Harvard Medical School / Massachusetts General Hospital Cancer Center

  • 2005

    Leopoldina Prize for Young Scientists from the Leopoldina German Academy of Natural Scientists

  • 2005

    Doctorate Prize of the German Society for Haematology & Oncology (DGHO)

  • 2003/2007

    Scholar-in-Training Awards of the American Association for Cancer Research

  • 2002-2004

    Doctoral Student at the University of Muenster, Clinic for Internal Medicine A (Haematology/Oncology)

  • 1999-2002

    Undergraduate Student of Biochemistry at the University of Witten/Herdecke

  • 1996-2004

    Scholarship from the German National Academic Foundation

  • 1996-1999

    Undergraduate Student of Biochemistry at the University of Tuebingen

Featured Publication

S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression", Cell (2007) 131: 1097-1108

S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression", Cell (2007) 131: 1097-1108

Die Aktivität der Gene im menschlichen Genom muss sehr präzise reguliert werden, da die Fehlregulation einzelner Gene schwere Krankheiten verursachen kann - zum Beispiel Krebs. Kleine RNA-Moleküle, sog. microRNAs, sind wichtige Regulatoren der Genaktivität. In dieser Studie (Cell 2007) konnten wir einen neuen Schritt in der Prozessierung dieser microRNAs entdecken sowie einen neuen Mechanismus zu deren Regulation identifizieren. Dies ist ein wichtiger Beitrag, um die Rolle von microRNAs in menschlichen Zellen zu verstehen und diese grundlegenden Erkenntnisse ließen sich bereits auf eine praktische Anwendung zur experimentellen oder therapeutischen Genregulation übertragen (PNAS 2008).

Activities

Publications

  • The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells

    T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR MacLeod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells", Cancer Research (2013) 73 http://cancerres.aacrjournals.org/content/early/2012/12/14/0008-5472.CAN-12-2850.abstract

  • Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases

    T Gutschner, M Baas, S Diederichs: "Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases", Genome Research (2011) 21: 1944-1954

  • Many roads to maturity: microRNA biogenesis pathways and their regulation

    J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation", Nature Cell Biology (2009) 11: 228-234

  • Co-expression of Argonaute-2 enhances RNA Interference towards perfect match binding sites

    S Diederichs, S Jung, SM Rothenberg, GA Smolen, BG Mlody, DA Haber: "Co-expression of Argonaute-2 enhances RNA Interference towards perfect match binding sites", Proceedings of the National Academy of Sciences U.S.A. (2008) 105: 9284-9289

  • Sequence Variations of microRNAs in human Cancer: Alterations in predicted secondary Structure do not affect Processing

    S Diederichs, DA Haber: "Sequence Variations of microRNAs in human Cancer: Alterations in predicted secondary Structure do not affect Processing", Cancer Research (2006) 66: 6097-6104

  • Publication list

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